Pukeon

Pukeon is Ondansetron injection available in 2ml ampoule for Intramascular & Intravenous use. Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Therapy Area: Surgeon / Physician

Form: Ampoules IM / IV

Packaging: : Tray of 1*10 amp.

Composition: Ondansetron (as HCl dihydrate) 2mg/ml (IV or IM inj).

Dose

Ondansetron may be administered as a single dose of 4 mg given by intramuscular or slow intravenous injection at induction of anesthesia.

For treatment of established PONV: A single dose of 4 mg given by intramuscular or slow intravenous injection is recommended.

Adult Dosage:

Chemotherapy (vials must be diluted ): >18yrs: Infuse over 15 mins. 0.15mg/kg (max 16mg/dose) IV every 4hrs for 3 doses beginning 30 mins before chemotherapy. Severe hepatic dysfunction: max 8mg/day.

Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2-5 minutes 4mg IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs. Or, may use 4mg IM undiluted as a single injection.

Children Dosage:

Chemotherapy (vials must be diluted): Infuse over 15 mins. < 6 months-18yrs: 0.15mg/kg (max 16mg/dose) IV for 3 doses every 4hrs beginning 30 mins before chemotherapy. Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2-5 mins: < 1 month-12yrs (<40kg): 0.1mg/kg. ≥40kg: 4mg. Give IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs.